Abstract
The optimisation of a new series of high potency muscarinic M3 antagonists, derived from high throughput screening library hit is described.
Copyright © 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Drug Evaluation, Preclinical
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Hepatocytes / metabolism
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Humans
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Microsomes / metabolism
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Rats
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Receptor, Muscarinic M3 / antagonists & inhibitors*
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Receptor, Muscarinic M3 / metabolism
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Spiro Compounds / chemical synthesis
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Spiro Compounds / chemistry*
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Spiro Compounds / pharmacology
Substances
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Receptor, Muscarinic M3
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Spiro Compounds